The physiological micro systems of these organs on the chip can accurately predict the response of the human body to different drugs or external stimuli by simulating the relationship between the main structural functions of different tissues and complex organs of the human body in vitro and this makes it have broad application prospects in life sciences and medical research new drug . Buy drug distribution in the body in vitro prediction and physiological interpretation the cat as an in vivo model for myocardial ischemia and infarction in pharmacology and clinical pharmacology by p h hinderling k schror e f iii smith allan m lefer isbn 9780895742728 from amazons book store everyday low prices and free delivery on eligible orders. Drug distribution in the body in vitro prediction and physiological interpretation the cat as an in vivo model for myocardial ischemia and infarction p h hinderling k schror e f iii smith allan m lefer 9780895742728 books amazonca. In vitro models can be used simply to describe the effect of a drug on a bacterial population as well as to provide data for more analytical studies including hypothesis testing analytical study designs provide information on the pharmacodynamic parameter best related to the chosen outcome as well as its magnitude factors such as the characteristics of the model method of drug removal . For 11 drugs it was investigated whether tissue distribution in vivo can be predicted by use of binding data obtained in vitro the selection of drugs represented a broad spectrum of physicochemical and pharmacokinetic properties thought to be important for distribution of drugs in vivo the extent of binding to plasma and to tissue homogenates of rabbits was determined in vitro the drug concentrations in plasma liver lungs kidneys and skeletal muscle of rabbits were determined in vivo